Phd (2004)

Professional Biography

I have been heavily involved with the development of statistical algorithms for microarray data analysis, including spending a great deal of time as a member of Terry Speed's group at UC Berkeley from 1999-2004.
I developed the Quantile Normalization algorithm and showed that it performed well for microarray data. Working with several collaborators I created the RMA algorithm for producing expression measures for Affymetrix GeneChip data. A great deal of my research has focused on the development and application of Probe Level Models (PLM) for the analysis of high-density oligonucleotide array data. One interesting application of PLM is for the quality assessment of GeneChip data. The PLM Image Gallery contains a number of images demonstrating the results of these techniques.
In 2005 I spent time at Predicant Biosciences developing statistical and computational techinques for the analysis of mass spectrometry data.
Starting in 2006 I began working for Affymetrix where I create algorithmic pipelines for processing and analyzing copy number data focused on both Constitutional Cytogenetics and Cancer applications. Some of the products I have help develop include CytoScan HD, CytoScan Dx, OncoScan and CytoScan XON.
In 2016, Affymetrix was acquired by Thermo Fisher Scientific, where I currently remain employed.
My linkedin profile.